{"id":913,"date":"2026-01-09T16:00:28","date_gmt":"2026-01-09T13:00:28","guid":{"rendered":"https:\/\/farmaciauniversitara.ro\/?p=913"},"modified":"2026-01-10T09:29:51","modified_gmt":"2026-01-10T06:29:51","slug":"sztatinok-es-grapefruit-a-potencialisan-veszelyes-kombinacio","status":"publish","type":"post","link":"https:\/\/farmaciauniversitara.ro\/hu\/sztatinok-es-grapefruit-a-potencialisan-veszelyes-kombinacio\/","title":{"rendered":"Sztatinok \u00e9s grapefruit: a potenci\u00e1lisan vesz\u00e9lyes kombin\u00e1ci\u00f3"},"content":{"rendered":"<h2><strong>Mik azok a sztatinok \u00e9s mire haszn\u00e1ljuk \u0151ket?<\/strong><\/h2>\n<p><span style=\"font-weight: 400;\">A sztatinok olyan gy\u00f3gyszerek, amelyek cs\u00f6kkentik az LDL-koleszterin (\u201erossz koleszterin\u201d) szintj\u00e9t, emellett kis m\u00e9rt\u00e9kben n\u00f6velik a HDL-koleszterin (\u201ej\u00f3 koleszterin\u201d) szintj\u00e9t, hozz\u00e1j\u00e1rulva a kardiovaszkul\u00e1ris kock\u00e1zat cs\u00f6kkent\u00e9s\u00e9hez. Gyakran \u00edrj\u00e1k fel magas koleszterinszint eset\u00e9n, \u00e9s hossz\u00fa t\u00e1von kell haszn\u00e1lni \u0151ket. A szimvasztatin, atorvasztatin vagy roszuvasztatin (kereskedelmi neveken, mint Simvacard, Sortis, Atoris, Crestor, Rosucard, Roswera) <\/span><a href=\"https:\/\/www.intechopen.com\/chapters\/71581\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">a ter\u00e1pi\u00e1ban leggyakrabban haszn\u00e1lt sztatinok.<\/span><\/a><\/p>\n<h3><strong>Az interakci\u00f3 a grapefruittal \u2013 \u00e9rdemes tudni r\u00f3la<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">Kevesen tudj\u00e1k, hogy bizonyos \u00e9lelmiszerek befoly\u00e1solhatj\u00e1k a gy\u00f3gyszerek hat\u00e1s\u00e1t. Klasszikus p\u00e9lda a grapefruit, <\/span><a href=\"https:\/\/japsonline.com\/abstract.php?article_id=4218&amp;sts=2\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">amely bizonyos sztatinokkal k\u00f6lcs\u00f6nhat\u00e1st mutat<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">A grapefruit (maga a gy\u00fcm\u00f6lcs \u00e9s a grapefruitl\u00e9 is) furanokumarinokat tartalmaz, amelyek g\u00e1tolj\u00e1k a CYP3A4 enzim aktivit\u00e1s\u00e1t, amely a m\u00e1jban \u00e9s a b\u00e9lfalban is megtal\u00e1lhat\u00f3. Ez az enzim sz\u00e1mos gy\u00f3gyszer, k\u00f6zt\u00fck egyes sztatinok metabolizmus\u00e1ban vesz r\u00e9szt. <\/span><a href=\"http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567568802000028\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">A CYP3A4 g\u00e1tl\u00e1sa eset\u00e9n a v\u00e9r\u00e1ramba jut\u00f3 gy\u00f3gyszer mennyis\u00e9ge jelent\u0151sen megn\u0151, ami vesz\u00e9lyes mell\u00e9khat\u00e1sokhoz vezethet<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h3><strong>Mely sztatinokra \u00e9rv\u00e9nyes ez?<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">Az interakci\u00f3 nem minden sztatinn\u00e1l jelentkezik. Leg\u00e9rz\u00e9kenyebbek a szimvasztatin, lovasztatin vagy atorvasztatin. Ezeket f\u0151k\u00e9nt a CYP3A4 enzim metaboliz\u00e1lja, <\/span><a href=\"https:\/\/journals.sagepub.com\/doi\/10.1177\/1715163518768534\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">\u00edgy a grapefruit g\u00e1tl\u00e1sa n\u00f6veli a plazmakoncentr\u00e1ci\u00f3t<\/span><\/a><span style=\"font-weight: 400;\">, fokozva a kock\u00e1zatot:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">miomiop\u00e1tia (izomf\u00e1jdalom)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">rabdomiol\u00edzis (s\u00falyos izomprobl\u00e9ma)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">hepatotoxicit\u00e1s (m\u00e1jk\u00e1rosod\u00e1s)<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: 400;\">Egy poh\u00e1r grapefruitl\u00e9 naponta, <\/span><a href=\"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2125.2004.02095.x\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">megk\u00e9tszerezheti a szimvastatin v\u00e9rszintj\u00e9t<\/span><\/a><span style=\"font-weight: 400;\">. Fontos tudni, hogy a sztatinok \u00e9s a grapefruit k\u00f6z\u00f6tti k\u00f6lcs\u00f6nhat\u00e1s a fogyaszt\u00e1s id\u0151pontj\u00e1t\u00f3l f\u00fcggetlen\u00fcl jelentkezik, az id\u0151beni elk\u00fcl\u00f6n\u00edt\u00e9s \u00f6nmag\u00e1ban nem elegend\u0151 ennek a hat\u00e1snak a megel\u0151z\u00e9s\u00e9re.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">A roszuvastatint, fluvasztatint vagy pravasztatint tartalmaz\u00f3 gy\u00f3gyszerek hat\u00e1s\u00e1t a grapefruitl\u00e9 fogyaszt\u00e1sa kev\u00e9sb\u00e9 foly\u00e1solja be. <\/span><a href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1517\/17425255.3.1.67\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Ezeket m\u00e1s enzimek metaboliz\u00e1lj\u00e1k<\/span><\/a><span style=\"font-weight: 400;\"> (pl. a CYP2C9), \u00edgy a k\u00f6lcs\u00f6nhat\u00e1s kock\u00e1zata sokkal kisebb.<\/span><\/p>\n<p><strong>Gyakorlati tan\u00e1csok betegeknek<\/strong><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">ker\u00fclje a grapefruit fogyaszt\u00e1s\u00e1t, ha szimvasztatint, atorvasztatint vagy lovasztatint szed.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Besz\u00e9ljen az orvos\u00e1val vagy gy\u00f3gyszer\u00e9sz\u00e9vel kezel\u00e9si alternat\u00edv\u00e1kr\u00f3l.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ne hagyja abba vagy ne v\u00e1ltoztasson a kezel\u00e9sen orvosi konzult\u00e1ci\u00f3 n\u00e9lk\u00fcl.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ha izomf\u00e1jdalmat, g\u00f6rcs\u00f6ket vagy izomgyenges\u00e9get tapasztal sztatin kezel\u00e9s alatt, forduljon orvoshoz vagy gy\u00f3gyszer\u00e9szhez, akik javasolhatj\u00e1k a kreatin-kin\u00e1z vizsg\u00e1latot \u2013 ez egy laborat\u00f3riumi teszt, amely seg\u00edts\u00e9g\u00e9vel kor\u00e1n felismerhet\u0151 az izomk\u00e1rosod\u00e1s \u00e9s megel\u0151zhet\u0151k az esetleges sz\u00f6v\u0151dm\u00e9nyek.<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><strong>Mit tehetnek a gy\u00f3gyszer\u00e9szek?<\/strong><\/p>\n<p><span style=\"font-weight: 400;\">Az olyan gy\u00f3gyszert\u00e1rak, mint a GAUDEAMUS Egyetemi Gy\u00f3gyszert\u00e1r, szem\u00e9lyre szabott tan\u00e1csad\u00e1st ny\u00fajtanak a gy\u00f3gyszerk\u00f6lcs\u00f6nhat\u00e1sokkal kapcsolatban, speci\u00e1lis szoftverek (p\u00e9ld\u00e1ul a Lexicomp) \u00e9s val\u00f3s idej\u0171 szakmai konzult\u00e1ci\u00f3 mellett, egy erre a c\u00e9lra kialak\u00edtott, nyugodt k\u00f6rnyezetben, ahol a gy\u00f3gyszer\u00e9sz \u00e9s a beteg k\u00f6z\u00f6tt \u00e9rdemi p\u00e1rbesz\u00e9d alakulhat ki. Ez j\u00f3 p\u00e9ld\u00e1ja a betegk\u00f6zpont\u00fa digitaliz\u00e1ci\u00f3nak, ahol a kezel\u00e9s biztons\u00e1ga els\u0151dleges szempont<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: 400;\">Irodalom:<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Cid-Conde L, L\u00f3pez-Castro J, Cid-Conde L, et al. Pharmacokinetic Aspects of Statins. <\/span><i><span style=\"font-weight: 400;\">Cardiovascular Risk Factors in Pathology<\/span><\/i><span style=\"font-weight: 400;\">. Epub ahead of print 28 March 2020. DOI:<\/span><a href=\"https:\/\/doi.org\/10.5772\/intechopen.91910\" target=\"_blank\" rel=\"noopener\"> <span style=\"font-weight: 400;\">https:\/\/doi.org\/10.5772\/intechopen.91910<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Dayyih WA, Al-Ani I, Hailat M, et al. Review of grapefruit juice-drugs interactions mediated by intestinal CYP3A4 inhibition. <\/span><i><span style=\"font-weight: 400;\">J Appl Pharm Sci<\/span><\/i><span style=\"font-weight: 400;\"> 2024; 14,: 059\u2013068. DOI:<\/span><a href=\"https:\/\/dx.doi.org\/10.7324\/JAPS.2024.160197\" target=\"_blank\" rel=\"noopener\"> <span style=\"font-weight: 400;\">https:\/\/dx.doi.org\/10.7324\/JAPS.2024.160197<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Paoletti R, Corsini A, Bellosta S. Pharmacological interactions of statins. <\/span><i><span style=\"font-weight: 400;\">Atheroscler Suppl<\/span><\/i><span style=\"font-weight: 400;\"> 2002; 3: 35\u201340. DOI:<\/span><a href=\"https:\/\/doi.org\/10.1016\/s1567-5688(02)00002-8\" target=\"_blank\" rel=\"noopener\"> <span style=\"font-weight: 400;\">https:\/\/doi.org\/10.1016\/s1567-5688(02)00002-8<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Barry AR, Beach JE, Pearson GJ. Prevention and management of statin adverse effects: A practical approach for pharmacists. <\/span><i><span style=\"font-weight: 400;\">Canadian Pharmacists Journal<\/span><\/i><span style=\"font-weight: 400;\"> 2018; 151: 179\u2013188.DOI:<\/span><a href=\"https:\/\/doi.org\/10.1177\/1715163518768534\" target=\"_blank\" rel=\"noopener\"> <span style=\"font-weight: 400;\">https:\/\/doi.org\/10.1177\/1715163518768534<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Lilja JJ, Neuvonen M, Neuvonen PJ. Effects of regular consumption of grapefruit juice on the pharmacokinetics of simvastatin. <\/span><i><span style=\"font-weight: 400;\">Br J Clin Pharmacol<\/span><\/i><span style=\"font-weight: 400;\"> 2004; 58: 56\u201360. DOI:<\/span><a href=\"https:\/\/doi.org\/10.1111\/j.1365-2125.2004.02095.x\" target=\"_blank\" rel=\"noopener\"> <span style=\"font-weight: 400;\">https:\/\/doi.org\/10.1111\/j.1365-2125.2004.02095.x<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Paine MF, Oberlies NH. Clinical relevance of the small intestine as an organ of drug elimination: Drug &#8211; fruit juice interactions. <\/span><i><span style=\"font-weight: 400;\">Expert Opin Drug Metab Toxicol<\/span><\/i><span style=\"font-weight: 400;\"> 2007; 3: 67\u201380. DOI:<\/span><a href=\"https:\/\/doi.org\/10.1517\/17425255.3.1.67\" target=\"_blank\" rel=\"noopener\"> <span style=\"font-weight: 400;\">https:\/\/doi.org\/10.1517\/17425255.3.1.67<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mik azok a sztatinok \u00e9s mire haszn\u00e1ljuk \u0151ket? A sztatinok olyan gy\u00f3gyszerek, amelyek cs\u00f6kkentik az LDL-koleszterin (\u201erossz koleszterin\u201d) szintj\u00e9t, emellett kis m\u00e9rt\u00e9kben n\u00f6velik a HDL-koleszterin (\u201ej\u00f3 koleszterin\u201d) szintj\u00e9t, hozz\u00e1j\u00e1rulva a kardiovaszkul\u00e1ris kock\u00e1zat cs\u00f6kkent\u00e9s\u00e9hez. Gyakran \u00edrj\u00e1k fel magas koleszterinszint eset\u00e9n, \u00e9s hossz\u00fa t\u00e1von kell haszn\u00e1lni \u0151ket. A szimvasztatin, atorvasztatin vagy roszuvasztatin (kereskedelmi neveken, mint Simvacard, Sortis, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":912,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-913","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/farmaciauniversitara.ro\/hu\/wp-json\/wp\/v2\/posts\/913","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/farmaciauniversitara.ro\/hu\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/farmaciauniversitara.ro\/hu\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/farmaciauniversitara.ro\/hu\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/farmaciauniversitara.ro\/hu\/wp-json\/wp\/v2\/comments?post=913"}],"version-history":[{"count":5,"href":"https:\/\/farmaciauniversitara.ro\/hu\/wp-json\/wp\/v2\/posts\/913\/revisions"}],"predecessor-version":[{"id":918,"href":"https:\/\/farmaciauniversitara.ro\/hu\/wp-json\/wp\/v2\/posts\/913\/revisions\/918"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/farmaciauniversitara.ro\/hu\/wp-json\/wp\/v2\/media\/912"}],"wp:attachment":[{"href":"https:\/\/farmaciauniversitara.ro\/hu\/wp-json\/wp\/v2\/media?parent=913"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/farmaciauniversitara.ro\/hu\/wp-json\/wp\/v2\/categories?post=913"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/farmaciauniversitara.ro\/hu\/wp-json\/wp\/v2\/tags?post=913"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}